Study Identifies How Tamoxifen Stimulates Uterine Cell Growth And Cancer
View Original ArticleSat, 04 Jul 2009 01:00:00 PDT UCSF researchers have identified a new "feed-forward" pathway linking estrogen receptors in the membrane of the uterus to a process that increases local estrogen levels and promotes cell growth. The research is significant in helping determine why tamoxifen and other synthetic estrogens are linked to increased rates of endometriosis and uterine cancer, and identifies a pathway that could be targeted in drug therapies for those diseases, researchers say.
Connection Between Cancer And Human Evolution Revealed By Ben-Gurion U. Researchers
View Original ArticleSat, 04 Jul 2009 01:00:00 PDT Researchers at Ben-Gurion University of the Negev (BGU) have discovered that gene mutations that once helped humans survive may increase the possibility for diseases, including cancer. The findings were recently the cover story in the journal Genome Research.
Improving The Biomarker Pipeline For Early Cancer Detection
View Original ArticleSat, 04 Jul 2009 00:00:00 PDT Several statistical and biological issues need to be addressed in order to improve biomarker identification for early detection of cancer, according to a commentary published online July 2 in the Journal of the National Cancer Institute. The biomarker pipeline to develop and evaluate cancer screening tests includes the identification of promising biomarkers to detect cancers early and the initial and definitive evaluation of biomarkers for cancer screening.
Hepatitis B Virus Mutations May Predict Risk Of Liver Cancer
View Original ArticleSat, 04 Jul 2009 00:00:00 PDT Certain mutations in the DNA of the hepatitis B virus (HBV) are associated with the development of liver cancer and may help predict which patients with HBV infections are at increased risk of the disease, according to a large meta-analysis in the Journal of the National Cancer Institute, published online July 2. HBV infection is a known cause of hepatocellular carcinoma (HCC), the most common form of liver cancer.
Work Status Changes More Common Among Women Receiving Chemotherapy For Breast Cancer, Study Says
View Original ArticleFri, 03 Jul 2009 03:00:00 PDT Women with breast cancer who receive chemotherapy appear more likely than those treated with radiation therapy to experience a major change in work status, according to a study published in the journal Cancer, Reuters reports. For the study,