Disability Resource Directory

View Original Article Tue, 15 Jul 2008 00:00:00 PDT
Neurogen Corporation (Nasdaq: NRGN) announced that, as planned, it commenced a Phase 2/3 clinical trial in chronic insomnia patients with the Company's insomnia agent, adipiplon and that, based upon reports from initial dosing of a higher than anticipated rate of unwanted next day effects, the Company has suspended dosing in the study. Neurogen believes that the bilayer tablet formulation of adipiplon being used in the study may not be performing as expected.

View Original Article Tue, 08 Jul 2008 01:00:00 PDT
Two studies in the July 1 issue of the journal Sleep analyze menopausal sleep problems, finding that complaints may differ according to the stage of menopausal transition and the ethnicity of the woman, and identifying risk factors that may predict sleep problems at any stage of menopause. A multi-ethnic study of more than 3,000 women shows that the odds of having trouble falling asleep and staying asleep increase through the menopausal transition.

View Original Article Tue, 08 Jul 2008 01:00:00 PDT
A study in the July 1 issue of the journal Sleep provides visual evidence of the severe structural damage that occurs in numerous regions of the brain in people with obstructive sleep apnea (OSA). Results show that OSA patients have extensive alterations in "white matter," nerve tissue in the brain containing fibers that are insulated with myelin - a white, fatty sheath.

View Original Article Tue, 08 Jul 2008 00:00:00 PDT
A study in the July 1 issue of the journal Sleep shows that episodes of sleep-disordered breathing accompanied by mild oxygen desaturations of as little as two percent are associated with hyperglycemia. Adults with 11 or more apnea-hypopnea events per hour with an oxygen desaturation of 2.0 percent to 2.9 percent had an adjusted cumulative odds ratio of 1.41 for impaired fasting glucose or diabetes.

View Original Article Tue, 08 Jul 2008 00:00:00 PDT
Treating pediatric obstructive sleep apnea (OSA) with either orthodontic expansion or adenotonsillectomy improves symptoms, but most young children need both treatments to have complete resolution of OSA symptoms, according to a study in the July 1 issue of the journal Sleep.